Cigarettafüst-indukálta gyulladásos folyamatok COPD-ben – szisztémás gyulladás kialakulása a Wnt5a és a gyulladásos citokin tartalmú extracelluláris vezikulák által

Abstract

COPD is an irreversible condition of airflow limitation characterized by inflammation and impaired respiratory gas exchange. The prevalence of COPD is approximately 10% among individuals older than 40 years of age. Furthermore, based on recent statistics, COPD is the seventh and fourth highest cause of disability and death worldwide, respectively. The main cause of COPD is tobacco smoking, but other factors, such as air pollution, occupational hazards, and infections can also initiate the disease. Despite all the therapeutic efforts, COPD is irreversible and progressive in nature. Although COPD is recognized primarily as a lung disease, it has systemic manifestations and the comorbidities affect the heart, pancreas, skeletal muscle. To suppress systemic inflammation, glucocorticoid therapy is used to treat acute exacerbations of the disease. Apart from the limited efficacy, side effects occur including histone deacetylase regulated resistance to corticosteroids. To find a permanent cure for COPD, more research on drug target identification and disease pathomechanism is required.