A TRP csatornák és szenzoros neuropeptidek szerepe az orrnyálkahártya gyulladásos megbetegedéseiben

Abstract

Chronic rhinosinusitis (CRS) is multifactorial and characterized by chronic inflammation of the sinonasal mucosa and its exact ethiology is still unclear. The limitations of earlier assumptions about CRS that it is an incomplete or therapeutically resistant form of acute rhinosinusitis (ARS) has led to the emergence of many alternative hypotheses, but no unified consensus has emerged so far. According to the classical theory of the 1980s, the development of the disease begins with the occlusion of the osteomeatal complex (OMC) resulting in inflammation due to the blockage of ventilation and drainage. This was followed by the epithel rupture theory according that during inflammation and edema of the nasal mucosa small injuries form that lead to neovascularization and thus polyp formation. A new attempt was made by the fungal theory at the end of the 1990s, which means that all CRS are based on a powerful inflammatory reaction to the Alternaria species. The definition of eosinophilic fungal rhinosinusitis associated with Ponikau and the role of fungus in CRS has fallen for a decade. The fungus, as an influencing factor, changes the character and course of the disease in some CRS variants.