Fej-nyaki daganatok mikrokörnyezetének molekuláris vizsgálata

Abstract

More than 90% of head and neck cancers are squamous cell cancers with a 5-year survival rate of only around 60%. Tumors are often diagnosed in an advanced stage due to the lack of specific symptoms and diagnostic difficulties. The more advanced the stage of the tumor, the more invasive the diagnostic and therapeutic interventions required. Therefore, early molecular diagnosis could be of pivotal importance primarily with respect to increasing the survival rate. Recent decades failed to see an improvement in survival rates despite development in diagnostic and therapeutic methods. The aims of the thesis were originated from these data – a more widely-available method would be needed which could enable early diagnosis of the tumors and would also be suitable for follow-up.