Clinical impact of high platelet reactivity and platelet function test based antiplatelet treatment strategy in patients after percutaneous coronary intervention

Abstract

The long-term success of myocardial revascularisation requires the optimisation of pharmacological and interventional treatment protocols which consider both the thrombotic and bleeding complications. However, the treatment based on the current therapeutic recommendations still fails to fully eliminate these adverse events after percutaneous coronary intervention (PCI). The short – and long-term results of PCI are multifactorial and depend on the clinical setting (chronic coronary syndrome or acute coronary syndrome), the complexity of the coronary disease, the operator experience, the patient status and comorbidities. The most important ischemic complications after PCI include recurrent ischemia due to the thrombosis of the previously stented segment or the overproliferation of the intimal layer of the treated vessel which leads to thickened neointima and reduced vessel lumen.